|
|
|
 |
|
1150 17th Street NW
Suite 850
Washington, DC
20036
(202) 223.2226
1 (800) 231.4222 |
|
|
|
|
 Professionals
Research
Grants |
|
The National Osteoporosis Foundation
2008 Research Grant Recipients
 |
Edward C. Hsiao, MD, PhD
J. David Gladstone Institutes
Identification of G-Protein Coupled Receptors in Osteoblastogenesis
With the support of the NOF, this project will identify and study the native hormone receptors that help regulate bone formation. The results will also identify potential new targets for controlling bone growth, both in diseases of bone loss such as osteoporosis and in diseases of excess bone formation such as heterotopic bone ossification. |
 |
Susan Reinwald, BA, MS, PhD
Indiana University
Menopause, Type II Diabetes and the Underlying Link to Bone Fragility
Chronic hyperglycemia is known to alter the functionality of collagen cross-links which makes bones more fragile. Using an estrogen-deficient rat model that mimics human type 2 diabetes, the changes in bone matrix properties attributable to a condition of estrogen deficiency and hyperglycemia will be assessed. Pyridoxamine, a form of vitamin B6, will be evaluated as a therapeutic measure to limit dysfunctional cross-linking in bone collagen and protect against
detrimental changes to bone biomechanical properties in these rats. |
 |
Robyn Kimberly Fuchs, BS, MS, PhD
Indiana University
The Role of Periostin in Regulation Bone Size in Response to Anabolic Therapy
Fractures related to osteoporosis are a serious worldwide health problem that have devastating consequences on an individual’s quality of life and life expectancy. Developing novel therapies that function to increase bone strength and reduce the risk for fracture are highly desirable. This grant focuses on understanding how periosteal apposition is regulated by evaluating the novel extracellular matrix protein periostin which is found to be preferentially expressed in periosteal osteoblasts (bone forming cells). |
 |
Yi-Hsiang Hsu, ScD
Hebrew Rehabilitation Center, Institute for Aging Research
Osteocalcin and Metabolic Risk Factors
A Genome-Wide Association Study in Framingham
Dr. Hsu’s research is focused on the genetic determinants and gene-environment
interactions of osteoporosis, type 2 diabetes and metabolic
syndrome. He is currently working on genome-wide association
studies (GWAS) of osteoporosis-related phenotypes and body
composition in Framingham Cohorts (FHS SHARe). |
 2009 Research Grant Program
Download the Research Grant Handbook
 Top
of the
page
|
| |
|
