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National Osteoporosis Foundation highlights lay abstracts from ISO 9 - Joint NOF-ASBMR Session: New Horizons in Bone Research
In this session, Dr. Khosla will explore the future of osteoporosis therapies including new pathways under investigation and other promising therapeutic agents in development.
Estrogen plays a key role in building and maintaining bone in both men and women. Other sex hormones will be discussed as well to show the different effects each has in the body. It may be possible to use levels of follicle stimulating hormone (FSH) in the blood as a marker to estimate the degree of bone loss during menopause.
Cells throughout the body are able to “talk” to each other by secreting substance, proteins, to signal and turn on different cell actions. Depending on the part of the signaling pathway affected, this action may result in bone loss or bone gain. Dr. Khosla will discuss the WNT (“wint”) pathway and talk about how bone loss, bone gain as well as changes in bone structure may be stimulated by affecting any one of several points in the cycle. One protein in particular, sclerostin, will be examined in greater detail to illustrate its potential as a target for drug development.
Sundeep Khosla, MD is the Dr. Francis Chucker and Nathan Landow Research Professor of Medicine and Physiology, Mayo Foundation Distinguished Investigator, and an Associate Director for Research at the College of Medicine, Mayo Clinic. Dr. Khosla’s research interests include mechanisms of postmenopausal and age-related bone loss, sex steroid regulation of bone metabolism, and osteoblast/stem cell biology. Dr. Khosla has served as chair of the National Institutes of Health Skeletal Biology Development and Disease Study Section and on the Council of the National Institute on Aging. He has received numerous awards and honors for his work, including the Frederic C. Bartter Award for Clinical Investigation from the American Society for Bone and Mineral Research, the Clinical Investigator Award and Lecture from the Endocrine Society, the Innovation Award from the National Osteoporosis Foundation, and election to the ASCI and AAP. He is currently serving as President of the American Society for Bone and Mineral Research.
Please visit www.nof-iso.org for complete meeting details and program agenda.
About the National Osteoporosis Foundation
Established in 1984, the National Osteoporosis Foundation, a leading community-focused health organization, is dedicated to the prevention of osteoporosis and broken bones, the promotion of strong bones for life and the reduction of human suffering through programs of awareness, education, advocacy and research. For more information on the National Osteoporosis Foundation, visit www.nof.org.
The latest
Last week, a Food and Drug Administration (FDA) Panel voted that the risks of calcitonin salmon outweigh the benefits for the treatment of postmenopausal osteoporosis. The panel joined health authorities around the world in reviewing the drug’s safety after two recent studies showed slightly higher rates of cancer among patients taking calcitonin. The panel voted against continued use of the drug by a narrow majority, pointing out that it has not been found very effective in preventing bone fractures.
In today's Washington Post article "Calcium and Vitamin D findings show that caring for your bones can be compilicated," NOF's senior clinical director, Dr. Felicia Cosman helps clear up some of the confusion around the recent and conflicting research on calcium and vitamin D. She says: "It’s confusing, even for doctors. But there’s a common thread: None of the heart or kidney risks were associated with calcium from food."
CIRCA, the leading international buyer of fine jewelry, diamonds and watches, announced a new partnership with NOF at a Generations of Strength luncheon at the Friars Club in New York City on February 26. To kick-off the partnership, CIRCA’s Acting CEO Mary L. Forté presented NOF Executive Director and CEO Amy Porter with a check for $25,000, to support NOF’s mission.
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